General design issue which should must be correct before sending campaign

• Gmail removes anything before the body tags
• Gmail doesn’t show the CSS style: left
• Gmail doesn’t show the CSS style for headers: font-family. You can use the HTML tag “font face” instead of, or in conjunction with your “font-family” CSS tag.

• Hotmail doesn’t show the CSS style: margin

• Outlook 2007 doesn’t show the CSS style: left
• Outlook 2007 doesn’t show the CSS style: width
• Outlook 2007 doesn’t support title tags for any html elements
• Outlook 2007 doesn’t support alt tags for images

This is some issue need to check first with your campaign which will help you improve your open rate .